Emerald: Protein crystallization

Grow Diffraction-Ready™ protein crystals with the Microcapillary Protein Crystallization System (MCPS™). Sparse matrix screening and optimization experiments can be carried out simultaneously. Crystals grow in ~10 nanoliter
“plugs” that are prepared in microfluidic channels within plastic CrystalCards. Protein crystals can be extracted from the Peel-Apart™ CrystalCard™ and subjected to cryo-crystallographic investigation.

Quick facts:

• Crystals easily extracted from Peel-Apart CrystalCards
• CrystalCards compatible with in situ X-ray diffraction
• ~22ìL protein sufficient for 96 condition gradients
• On-chip formulation of gradients for optimization

thinXXS Microtechnology AG has transferred the application of Emerald into a volume production (injection molding). thinXXS realized important features like e.g. peelable film for crystal extraction, hydrophobization of the channels as well as the customized platform.