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Tailor made microfluidic systems

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Trinean: Microplate “DropPlate”

Analysis of microliter droplets of DNA, RNA, protein or small compounds

Trinean develops and produces nanoliter spectrophotometers and consumables for the research and scientific market. Trinean’s unique polychromatic microplate reader combined with microfluidic microplates helps scientists around the globe to save time and money on costly samples and reagents while gaining in accuracy, all of which are important commodities for biotech applications.

Trinean’s first product is the DropSense96®, a multichannel spectrophotometer combined with disposable microfluidic microplates (DropPlate®16 and DropPlate96®), suitable for quick & precise spectral analysis of microliter droplets of DNA, RNA, protein or small compounds. Patents held by Trinean cover both microfluidic structures and multi-channelspectrometry for microliter sample handling.

 The Trinean DropPlate16 and 96 disposable were designed for use with the DropSense96. A single DropPlate 16 strip contains 16 input reservoirs for sample storage and fixed dual pathlength measurement structures. For high-throughput testing or testing in an automated workflow, the DropPlate 96 has been developed and provides 96 microfluidic structures per plate with dimensions identical to those of a standard 96-well plate (SBS standard), assuring compatibility with liquid handling robots.

For manual use, 1 to 6 DropPlates can be clicked upon a frame creating a flexible set-up for the measurement of 1 to 96 samples simultaneously. Moreover, the DropPlates can be reused until all input reservoirs have been filled.

Microfluidic CD4 cell counting device

Easy to use portable Point-of-Care system

Daktari’s first product will be Daktari CD4, a CD4 cell counting system portable and robust enough to be used anywhere, from a doctor’s office to the most remote settings. Combining groundbreaking innovations in microscale technologies with simplicity in design and use, Daktari brings this essential blood test to parts of the world where millions of people now have access to life-saving drugs, yet cannot receive the best treatment due to inadequate diagnostics.

As simple in concept and as easy to use as a glucose meter, Daktari technology overcomes the two critical barriers to point-of-care testing: complex sample preparation, and fragile, expensive optical sensors.

Microfluidics – Daktari’s sample preparation technology, known to specialists as microfluidic cell chromatography, isolates cells and other particles in a miniature sensing chamber, without pipetting, labels or reagents of any kind—none of the complex manual steps that take blood tests out of the hands of clinicians who work beyond the reach of sophisticated labs.

Electrochemical sensing – Daktari CD4 also takes advantage of a second innovation, lysate impedance spectroscopy. The system uses a simple sensor that counts the captured CD4 cells by measuring their internal contents electrically. A handheld instrument interprets the electrical signal, and reports the CD4 count within minutes.

Unencumbered by the lenses, cameras, filters or complex optics that put many diagnostic tests out of reach for clinics, health posts, and mobile caregivers, Daktari CD4 will put the power of accurate test results in the hands of the people who need them.

More information about this unique microfluidic product you will find at: www.daktaridx.com

Sophion Bioscience: HTS system QPlate

Unique Lab-on-Chip accelerates drug development

It takes about twelve years to bring a new drug component to the market and the time for developing processes has permanently increased during the last few years. But how can you accelerate drug development?

That was exactly the question asked by Sophion Bioscience A/S. So they developed together with thinXXS Microtechnology AG the QPlate – a completely new microfluidic lab on chip device, which considerably shortens the time for pharmaceutical companies to discover and develop new drugs for various disease areas.

The QPlate is the heart of Sophion’s QPatch HT and QPatch-16 systems. The systems allow for fully automated, parallel measurement of up to 48 ion channel currents in cell membranes (patch clamping). Ion channels are important targets in drug development since their controlled blocking or opening may have significant therapeutical effects.

So far, such measurements posed a true bottleneck as the manual methods were extremely time consuming and labor intensive.

The QPlate integrates three different functions: it houses up to 48 microfabricated silicon/glass chips for the parallel measurements, it provides the necessary microfluidics to make the device work, and it acts as both electric and fluidic interface between the microstructures and apparatus.

For the first time this microfluidic chip combines the advantages of:

  • micromolding,
  • silicon microprocessing and
  • printed circuit board technology.

As the result, the device integrates more functions than any other lab-on-chip on the market today!

Emerald: Protein crystallization

Customized Crystal Cards

Emerald BioSystems is a leading provider of sophisticated laboratory automation, software tools, and consumable products for gene to protein crystal structure research. Emerald BioSystems’ unique product offerings work together to provide integrated solutions for biotechnology.

Grow Diffraction-Ready™ protein crystals with the Microcapillary Protein Crystallization System (MCPS™). Sparse matrix screening and optimization experiments can be carried out simultaneously. Crystals grow in ~10 nanoliter
“plugs” that are prepared in microfluidic channels within plastic CrystalCards. Protein crystals can be extracted from the Peel-Apart™ CrystalCard™ and subjected to cryo-crystallographic investigation.

Quick facts:

  • Crystals easily extracted from Peel-Apart CrystalCards
  • CrystalCards compatible with in situ X-ray diffraction
  • ~22ìL protein sufficient for 96 condition gradients
  • On-chip formulation of gradients for optimization

thinXXS Microtechnology AG has transferred the application of Emerald into a volume production (injection molding). thinXXS realized important features like e.g. peelable film for crystal extraction, hydrophobization of the channels as well as the customized platform.




We would also like to point you to miracle.consultech.de
A collaborative project between 14 partners from universities, research institutions and companies from all over Europe. The term MIRACLE is an acronym of the projects title “Magnetic Isolation and moleculaR Analysis of single CircuLating and disseminated tumour cElls on chip”.

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